Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

BACKGROUND: Preeclampsia is a major complication of pregnancy with no medical treatment. It is associated with placental oxidative stress, hypoxia and inflammation leading to soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion and reduced placental growth factor (PlGF)....

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Detalles Bibliográficos
Autores principales: Brownfoot, Fiona C., Hannan, Natalie J., Cannon, Ping, Nguyen, Vi, Hastie, Roxanne, Parry, Laura J., Senadheera, Sevvandi, Tuohey, Laura, Tong, Stephen, Kaitu'u-Lino, Tu'uhevaha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442229/
https://www.ncbi.nlm.nih.gov/pubmed/30824385
http://dx.doi.org/10.1016/j.ebiom.2019.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442229/
https://www.ncbi.nlm.nih.gov/pubmed/30824385
http://dx.doi.org/10.1016/j.ebiom.2019.02.013

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