SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC(50) values were found to be in the micromolar to submicromolar range. T...

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Detalles Bibliográficos
Autores principales: Shalaby, Raed, Petzer, Jacobus P., Petzer, Anél, Ashraf, Usman M., Atari, Ealla, Alasmari, Fawaz, Kumarasamy, Sivarajan, Sari, Youssef, Khalil, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442233/
https://www.ncbi.nlm.nih.gov/pubmed/30915862
http://dx.doi.org/10.1080/14756366.2019.1593158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442233/
https://www.ncbi.nlm.nih.gov/pubmed/30915862
http://dx.doi.org/10.1080/14756366.2019.1593158

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