Cargando…

SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC(50) values were found to be in the micromolar to submicromolar range. T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shalaby, Raed, Petzer, Jacobus P., Petzer, Anél, Ashraf, Usman M., Atari, Ealla, Alasmari, Fawaz, Kumarasamy, Sivarajan, Sari, Youssef, Khalil, Ashraf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442233/ https://www.ncbi.nlm.nih.gov/pubmed/30915862 http://dx.doi.org/10.1080/14756366.2019.1593158

Ejemplares similares

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
por: Cloete, Stephanus J., et al.
Publicado: (2020)

Intrarenal Dopaminergic System Is Dysregulated in SS-Resp18(mutant) Rats
por: Ashraf, Usman M., et al.
Publicado: (2023)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
por: Guglielmi, Paolo, et al.
Publicado: (2019)

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?
por: Carradori, Simone, et al.
Publicado: (2022)

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity
por: Guglielmi, Paolo, et al.
Publicado: (2019)

The Design and Evaluation of an l-Dopa–Lazabemide Prodrug for the Treatment of Parkinson’s Disease
por: Hoon, Monique, et al.
Publicado: (2017)

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B
por: Iacovino, Luca G., et al.
Publicado: (2021)

Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
por: de Beer, Johannie, et al.
Publicado: (2020)

Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions
por: Mathew, Bijo, et al.
Publicado: (2021)

An assessment of solvent residue contaminants related to cannabis-based products in the South African market
por: Viviers, Hendrik Jacobus, et al.
Publicado: (2022)

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
por: Oh, Jong Min, et al.
Publicado: (2020)

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2022)

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
por: Sasidharan, Rani, et al.
Publicado: (2021)

Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
por: Sudevan, Sachithra Thazhathuveedu, et al.
Publicado: (2022)

Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B
por: Kong, Zhuo, et al.
Publicado: (2020)

From Monoamine Oxidase Inhibition to Antiproliferative Activity: New Biological Perspectives for Polyamine Analogs
por: Nordio, Giulia, et al.
Publicado: (2023)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
por: Secci, Daniela, et al.
Publicado: (2019)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

Hydroxy Chalcones and Analogs with Chemopreventive Properties
por: Birsa, Mihail Lucian, et al.
Publicado: (2023)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Smoking Related Diseases: The Central Role of Monoamine Oxidase
por: Rendu, Francine, et al.
Publicado: (2011)

Androgen receptor and monoamine oxidase polymorphism in wild bonobos
por: Garai, Cintia, et al.
Publicado: (2014)

Inhibition of Monoamine Oxidase by Stilbenes from Rheum palmatum
por: Wei, Bo, et al.
Publicado: (2016)

Mitochondrial Monoamine Oxidase: Another Player in Pulmonary Hypertension?
por: Sommer, Natascha, et al.
Publicado: (2021)

Recent advances on the role of monoamine oxidases in cardiac pathophysiology
por: Kaludercic, Nina, et al.
Publicado: (2023)

Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain
por: Cai, Lu, et al.
Publicado: (2016)

Characterization of a Long Non-Coding RNA, the Antisense RNA of Na/K-ATPase α1 in Human Kidney Cells
por: Fan, Xiaoming, et al.
Publicado: (2018)

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue
por: Haj Ahmed, Wiem, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of O(6)-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases
por: Hassan, Ahmed H. E., et al.
Publicado: (2023)

ASCO update—best of the best
por: Petzer, Andreas
Publicado: (2022)

Monoamine Oxidase and its Inhibition. CIBA Foundation Symposium 39
por: Bowers, Malcolm B.
Publicado: (1978)

Cannot write session to /tmp/vufind_sessions/sess_krpp096nvcq42b06o89bnjtskg