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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC(50) values were found to be in the micromolar to submicromolar range. T...

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Detalles Bibliográficos
Autores principales:	Shalaby, Raed, Petzer, Jacobus P., Petzer, Anél, Ashraf, Usman M., Atari, Ealla, Alasmari, Fawaz, Kumarasamy, Sivarajan, Sari, Youssef, Khalil, Ashraf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442233/ https://www.ncbi.nlm.nih.gov/pubmed/30915862 http://dx.doi.org/10.1080/14756366.2019.1593158

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