Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression

Compared to enhancers, silencers are notably difficult to identify and validate experimentally. In search for human silencers, we utilized H3K27me3-DNase I hypersensitive site (DHS) peaks with tissue specificity negatively correlated with the expression of nearby genes across 25 diverse cell lines....

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Detalles Bibliográficos
Autores principales: Huang, Di, Petrykowska, Hanna M., Miller, Brendan F., Elnitski, Laura, Ovcharenko, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442386/
https://www.ncbi.nlm.nih.gov/pubmed/30886051
http://dx.doi.org/10.1101/gr.247007.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442386/
https://www.ncbi.nlm.nih.gov/pubmed/30886051
http://dx.doi.org/10.1101/gr.247007.118

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