New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation

Many DNA methylome profiling methods cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Because 5mC typically acts as a repressive mark whereas 5hmC is an intermediate form during active demethylation, the inability to separate their signals could lead to incorrect...

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Detalles Bibliográficos
Autores principales: Li, Le, Gao, Yuwei, Wu, Qiong, Cheng, Alfred S.L., Yip, Kevin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442395/
https://www.ncbi.nlm.nih.gov/pubmed/30782641
http://dx.doi.org/10.1101/gr.240036.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442395/
https://www.ncbi.nlm.nih.gov/pubmed/30782641
http://dx.doi.org/10.1101/gr.240036.118

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