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Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5

Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity...

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Detalles Bibliográficos
Autores principales: Shukla, Arvind Kumar, Spurrier, Joshua, Kuzina, Irina, Giniger, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442473/
https://www.ncbi.nlm.nih.gov/pubmed/30605670
http://dx.doi.org/10.1016/j.celrep.2018.12.025