Cargando…

Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5

Mostrar otras versiones (1)

Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shukla, Arvind Kumar, Spurrier, Joshua, Kuzina, Irina, Giniger, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442473/ https://www.ncbi.nlm.nih.gov/pubmed/30605670 http://dx.doi.org/10.1016/j.celrep.2018.12.025

Ejemplares similares

Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5
por: Shukla, Arvind Kumar, et al.
Publicado: (2021)

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging
por: Spurrier, Joshua, et al.
Publicado: (2018)

The Abl/Enabled signaling pathway regulates Golgi architecture in Drosophila photoreceptor neurons
por: Kannan, Ramakrishnan, et al.
Publicado: (2014)

At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology
por: McLinden, Kristina A., et al.
Publicado: (2012)

Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila
por: Trunova, Svetlana, et al.
Publicado: (2012)

Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice
por: Lindahl, Maria, et al.
Publicado: (2019)

Common features of aging fail to occur in Drosophila raised without a bacterial microbiome
por: Shukla, Arvind Kumar, et al.
Publicado: (2021)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age
por: Costa, Giulia, et al.
Publicado: (2018)

Dopamine Transporter Imaging for Frontotemporal Lobar Degeneration With Motor Neuron Disease
por: Kobayashi, Ryota, et al.
Publicado: (2022)

Altered pattern of brain dopamine synthesis in male adolescents with attention deficit hyperactivity disorder
por: Forssberg, Hans, et al.
Publicado: (2006)

Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia
por: Liu, Hailan, et al.
Publicado: (2022)

The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations
por: Wodrich, Andrew P. K., et al.
Publicado: (2022)

Prenatal hypoxia alters the early ontogeny of dopamine neurons
por: Brandon, Anastasia, et al.
Publicado: (2022)

Enhanced Dopamine Transmission and Hyperactivity in the Dopamine Transporter Heterozygous Mice Lacking the D3 Dopamine Receptor
por: Sotnikova, Tatyana D., et al.
Publicado: (2020)

Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1
por: Pilotto, Federica, et al.
Publicado: (2023)

Cell-Type Specific Deletion of CB2 Cannabinoid Receptors in Dopamine Neurons Induced Hyperactivity Phenotype: Possible Relevance to Attention-Deficit Hyperactivity Disorder
por: Canseco-Alba, Ana, et al.
Publicado: (2022)

Sex differences in vocal communication of freely interacting adult mice depend upon behavioral context
por: Warren, Megan R., et al.
Publicado: (2018)

The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age
por: Kittappa, Raja, et al.
Publicado: (2007)

Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
por: Cao, Pengxiu, et al.
Publicado: (2010)

Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo
por: Bok, Eugene, et al.
Publicado: (2018)

Intermittent Fasting Applied in Combination with Rotenone Treatment Exacerbates Dopamine Neurons Degeneration in Mice
por: Tatulli, Giuseppe, et al.
Publicado: (2018)

Dilated Perivascular Space in the Midbrain May Reflect Dopamine Neuronal Degeneration in Parkinson’s Disease
por: Li, Yanxuan, et al.
Publicado: (2020)

O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease
por: Lee, Byeong Eun, et al.
Publicado: (2020)

Involvement of Cholinergic System in Hyperactivity in Dopamine-Deficient Mice
por: Hagino, Yoko, et al.
Publicado: (2015)

Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons
por: Fois, Giulia R., et al.
Publicado: (2022)

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
por: Maatouk, Layal, et al.
Publicado: (2018)

The Therapeutic Implications of Tea Polyphenols against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)
por: Zhou, Zhi Dong, et al.
Publicado: (2019)

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor
por: Coppens, Jessica, et al.
Publicado: (2017)

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
por: Costa, Giulia, et al.
Publicado: (2019)

Dopamine Appetite and Cognitive Impairment in Attention Deficit/Hyperactivity Disorder
por: Williams, Jonathan, et al.
Publicado: (2004)

Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
por: Fujita, Masayo, et al.
Publicado: (2022)

Diabetes Causes Dysfunctional Dopamine Neurotransmission Favoring Nigrostriatal Degeneration in Mice
por: Pérez‐Taboada, Iara, et al.
Publicado: (2020)

New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson’s Disease
por: Xu, Huamin, et al.
Publicado: (2018)

Cdk5 Phosphorylates Dopamine D2 Receptor and Attenuates Downstream Signaling
por: Jeong, Jaehoon, et al.
Publicado: (2013)

Vexed mutations promote degeneration of dopaminergic neurons through excessive activation of the innate immune response
por: Davis, Jacinta, et al.
Publicado: (2022)

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease
por: Song, Juhyun, et al.
Publicado: (2016)

A New Paradigm for Training Hyperactive Dopamine Transporter Knockout Rats: Influence of Novel Stimuli on Object Recognition
por: Kurzina, Natalia P., et al.
Publicado: (2021)

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo
por: Reinhardt, Lydia, et al.
Publicado: (2019)

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
por: Koprich, James B, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_rac2lir703qk6974tjie96ampp