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Point centromere activity requires an optimal level of centromeric noncoding RNA
In budding yeast, which possesses simple point centromeres, we discovered that all of its centromeres express long noncoding RNAs (cenRNAs), especially in S phase. Induction of cenRNAs coincides with CENP-A(Cse4) loading time and is dependent on DNA replication. Centromeric transcription is represse...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442628/ https://www.ncbi.nlm.nih.gov/pubmed/30850541 http://dx.doi.org/10.1073/pnas.1821384116 |