Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice

Insulin resistance and obesity are associated with reduced gonadotropin-releasing hormone (GnRH) release and infertility. Mice that lack insulin receptors (IRs) throughout development in both neuronal and non-neuronal brain cells are known to exhibit subfertility due to hypogonadotropic hypogonadism...

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Detalles Bibliográficos
Autores principales: Manaserh, Iyad H., Chikkamenahalli, Lakshmikanth, Ravi, Samyuktha, Dube, Prabhatchandra R., Park, Joshua J., Hill, Jennifer W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443191/
https://www.ncbi.nlm.nih.gov/pubmed/30893295
http://dx.doi.org/10.1371/journal.pbio.3000189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443191/
https://www.ncbi.nlm.nih.gov/pubmed/30893295
http://dx.doi.org/10.1371/journal.pbio.3000189

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