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Hfq‐dependent mRNA unfolding promotes sRNA‐based inhibition of translation

Small RNAs post‐transcriptionally regulate many processes in bacteria. Base‐pairing of sRNAs near ribosome‐binding sites in mRNAs inhibits translation, often requiring the RNA chaperone Hfq. In the canonical model, Hfq simultaneously binds sRNAs and mRNA targets to accelerate pairing. Here, we show...

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Detalles Bibliográficos
Autores principales: Hoekzema, Mirthe, Romilly, Cédric, Holmqvist, Erik, Wagner, E Gerhart H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443205/
https://www.ncbi.nlm.nih.gov/pubmed/30833291
http://dx.doi.org/10.15252/embj.2018101199