OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages

Upon viral infection, the 2′, 5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is unclear whether OAS proteins have a role in regulating gene expression. Here, we show that OAS1 and OAS3 act as negative regul...

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Detalles Bibliográficos
Autores principales: Lee, Wook-Bin, Choi, Won Young, Lee, Dong-Hyun, Shim, Hyeran, Kim-Ha, Jeongsil, Kim, Young-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443328/
https://www.ncbi.nlm.nih.gov/pubmed/30078389
http://dx.doi.org/10.5483/BMBRep.2019.52.2.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443328/
https://www.ncbi.nlm.nih.gov/pubmed/30078389
http://dx.doi.org/10.5483/BMBRep.2019.52.2.129

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