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OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages
Upon viral infection, the 2′, 5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is unclear whether OAS proteins have a role in regulating gene expression. Here, we show that OAS1 and OAS3 act as negative regul...
Autores principales: | Lee, Wook-Bin, Choi, Won Young, Lee, Dong-Hyun, Shim, Hyeran, Kim-Ha, Jeongsil, Kim, Young-Joon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443328/ https://www.ncbi.nlm.nih.gov/pubmed/30078389 http://dx.doi.org/10.5483/BMBRep.2019.52.2.129 |
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