Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR

The farnesoid X receptor (FXR) is known to regulate the gene expression of SR-BI, which mediates plasma high-density lipoprotein (HDL)-cholesterol uptake. Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepa...

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Detalles Bibliográficos
Autores principales: Dong, Bin, Singh, Amar B., Guo, Grace L., Young, Mark, Liu, Jingwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443341/
https://www.ncbi.nlm.nih.gov/pubmed/30896855
http://dx.doi.org/10.3892/ijmm.2019.4136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443341/
https://www.ncbi.nlm.nih.gov/pubmed/30896855
http://dx.doi.org/10.3892/ijmm.2019.4136

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