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Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR
The farnesoid X receptor (FXR) is known to regulate the gene expression of SR-BI, which mediates plasma high-density lipoprotein (HDL)-cholesterol uptake. Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443341/ https://www.ncbi.nlm.nih.gov/pubmed/30896855 http://dx.doi.org/10.3892/ijmm.2019.4136 |