Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure.

Cancer-causing genome instability is a major concern during space travel due to exposure of astronauts to potent sources of high-linear energy transfer (LET) ionizing radiation. Hematopoietic stem cells (HSCs) are particularly susceptible to genotoxic stress, and accumulation of damage can lead to H...

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Detalles Bibliográficos
Autores principales: Patel, Rutulkumar, Zhang, Luchang, Desai, Amar, Hoenerhoff, Mark J., Kennedy, Lucy H., Radivoyevitch, Tomas, Ban, Yuguang, Chen, Xi Steven, Gerson, Stanton L., Welford, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443507/
https://www.ncbi.nlm.nih.gov/pubmed/30275527
http://dx.doi.org/10.1038/s41375-018-0269-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443507/
https://www.ncbi.nlm.nih.gov/pubmed/30275527
http://dx.doi.org/10.1038/s41375-018-0269-8

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