A Fixed-Dose Combination, QXOH/Levobupivacaine, Produces Long-Acting Local Anesthesia in Rats Without Additional Toxicity

QXOH, a QX314 derivative with longer duration and lesser local toxicity, is a novel local anesthetic in preclinical drug development. Previous studies demonstrated that bupivacaine can prolong the effects of QX314. So, we attempted to combine QXOH with levobupivacaine to shorten the onset time and l...

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Detalles Bibliográficos
Autores principales: Yin, Qinqin, Zhang, Yujun, Lv, Rong, Gong, Deying, Ke, Bowen, Yang, Jun, Tang, Lei, Zhang, Wensheng, Zhu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443723/
https://www.ncbi.nlm.nih.gov/pubmed/30971919
http://dx.doi.org/10.3389/fphar.2019.00243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443723/
https://www.ncbi.nlm.nih.gov/pubmed/30971919
http://dx.doi.org/10.3389/fphar.2019.00243

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