Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Retinoid X receptor-alpha (RXRα) is a potent regulator of inflammatory responses; however, its therapeutic potential for inflammatory cancer remains to be explored. We previously discovered that RXRα is abnormally cleaved in tumor cells and tissues, producing a truncated RXRα (tRXRα). Here, we show...

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Detalles Bibliográficos
Autores principales: Ye, Xiaohong, Wu, Hua, Sheng, Luoyan, Liu, Yi-xin, Ye, Fang, Wang, Mo, Zhou, Hu, Su, Ying, Zhang, Xiao-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443775/
https://www.ncbi.nlm.nih.gov/pubmed/30931933
http://dx.doi.org/10.1038/s41467-019-09375-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443775/
https://www.ncbi.nlm.nih.gov/pubmed/30931933
http://dx.doi.org/10.1038/s41467-019-09375-8

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