Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways. Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint controls the fidelity of chromosome segregation during mitosis. Here, we show that insulin receptor substrate 1 and...

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Detalles Bibliográficos
Autores principales: Choi, Eunhee, Kikuchi, Sotaro, Gao, Haishan, Brodzik, Karolina, Nassour, Ibrahim, Yopp, Adam, Singal, Amit G., Zhu, Hao, Yu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443781/
https://www.ncbi.nlm.nih.gov/pubmed/30931927
http://dx.doi.org/10.1038/s41467-019-09318-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443781/
https://www.ncbi.nlm.nih.gov/pubmed/30931927
http://dx.doi.org/10.1038/s41467-019-09318-3

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