Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis

Drug tolerance in mycobacterial pathogens is a global concern. Fluoroquinolone (FQ) treatment is widely used for induction of persisters in bacteria. Although FQs that target DNA gyrase are currently used as second-line anti-tuberculosis (TB) drugs, little is known about their impact on Mycobacteriu...

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Detalles Bibliográficos
Autores principales: Choudhary, Eira, Sharma, Rishabh, Kumar, Yashwant, Agarwal, Nisheeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443821/
https://www.ncbi.nlm.nih.gov/pubmed/30972304
http://dx.doi.org/10.3389/fcimb.2019.00070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443821/
https://www.ncbi.nlm.nih.gov/pubmed/30972304
http://dx.doi.org/10.3389/fcimb.2019.00070

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