Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion

We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na(+),K(+)-ATPase α3 (NAKα3) is the sole target of amylospheroid-mediated neurodegeneration. However...

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Detalles Bibliográficos
Autores principales: Komura, Hitomi, Kakio, Shota, Sasahara, Tomoya, Arai, Yoshie, Takino, Naomi, Sato, Michio, Satomura, Kaori, Ohnishi, Takayuki, Nabeshima, Yo-ichi, Muramatsu, Shin-ichi, Kii, Isao, Hoshi, Minako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443839/
https://www.ncbi.nlm.nih.gov/pubmed/30827871
http://dx.doi.org/10.1016/j.isci.2019.01.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443839/
https://www.ncbi.nlm.nih.gov/pubmed/30827871
http://dx.doi.org/10.1016/j.isci.2019.01.018

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