Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells

The mechanism whereby 17β-estradiol (E2) mediates insulin gene transcription has not been fully elucidated. In this study, exposure of hamster insulinoma (HIT-T15) cells to 5 × 10(−9) to 1 × 10(−7) M E2 led to a concentration-dependent decrease of insulin mRNA levels. Transient expression of the est...

Descripción completa

Detalles Bibliográficos
Autores principales: Sekido, Takashi, Nishio, Shin-ichi, Ohkubo, Yohsuke, Sekido, Keiko, Kitahara, Junichiro, Miyamoto, Takahide, Komatsu, Mitsuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443913/
https://www.ncbi.nlm.nih.gov/pubmed/30790128
http://dx.doi.org/10.1007/s11626-019-00328-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443913/
https://www.ncbi.nlm.nih.gov/pubmed/30790128
http://dx.doi.org/10.1007/s11626-019-00328-5

Ejemplares similares