Cargando…
Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells
The mechanism whereby 17β-estradiol (E2) mediates insulin gene transcription has not been fully elucidated. In this study, exposure of hamster insulinoma (HIT-T15) cells to 5 × 10(−9) to 1 × 10(−7) M E2 led to a concentration-dependent decrease of insulin mRNA levels. Transient expression of the est...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443913/ https://www.ncbi.nlm.nih.gov/pubmed/30790128 http://dx.doi.org/10.1007/s11626-019-00328-5 |