Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer

Lenvatinib is a substrate of cytochrome P450 (CYP) 3A and ATP-binding cassette (ABC) transporters. In this study, we aimed to evaluate how CYP3A4/5 and ABC transporter polymorphisms affected the mean steady-state dose-adjusted plasma trough concentrations (C(0)) of lenvatinib in a cohort of 40 Japan...

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Detalles Bibliográficos
Autores principales: Ozeki, Tomoko, Nagahama, Mitsuji, Fujita, Kazuma, Suzuki, Akifumi, Sugino, Kiminori, Ito, Koichi, Miura, Masatomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443943/
https://www.ncbi.nlm.nih.gov/pubmed/30931962
http://dx.doi.org/10.1038/s41598-019-41820-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443943/
https://www.ncbi.nlm.nih.gov/pubmed/30931962
http://dx.doi.org/10.1038/s41598-019-41820-y

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