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Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Accurate variant calling and genotyping represent major limiting factors for downstream applications of single-cell genomics. Here, we report Conbase for the identification of somatic mutations in single-cell DNA sequencing data. Conbase leverages phased read data from multiple samples in a dataset...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444814/ https://www.ncbi.nlm.nih.gov/pubmed/30935387 http://dx.doi.org/10.1186/s13059-019-1673-8 |