Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing

Accurate variant calling and genotyping represent major limiting factors for downstream applications of single-cell genomics. Here, we report Conbase for the identification of somatic mutations in single-cell DNA sequencing data. Conbase leverages phased read data from multiple samples in a dataset...

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Detalles Bibliográficos
Autores principales: Hård, Joanna, Al Hakim, Ezeddin, Kindblom, Marie, Björklund, Åsa K., Sennblad, Bengt, Demirci, Ilke, Paterlini, Marta, Reu, Pedro, Borgström, Erik, Ståhl, Patrik L., Michaelsson, Jakob, Mold, Jeff E., Frisén, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444814/
https://www.ncbi.nlm.nih.gov/pubmed/30935387
http://dx.doi.org/10.1186/s13059-019-1673-8

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