Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer’s disease patients

An early pathological hallmark of Alzheimer’s disease (AD) is amyloid-β (Aβ) deposits in the brain, which largely consist of up to 43 amino acids long Aβ peptides derived from the amyloid precursor protein (APP). We previously identified a series of sialylated Tyr-10 O-glycosylated Aβ peptides, 15–2...

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Detalles Bibliográficos
Autores principales: Nilsson, Jonas, Brinkmalm, Gunnar, Ramadan, Sherif, Gilborne, Lisa, Noborn, Fredrik, Blennow, Kaj, Wallin, Anders, Svensson, Johan, Abo-Riya, Mohamed A., Huang, Xuefei, Larson, Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445081/
https://www.ncbi.nlm.nih.gov/pubmed/30940835
http://dx.doi.org/10.1038/s41598-019-41897-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445081/
https://www.ncbi.nlm.nih.gov/pubmed/30940835
http://dx.doi.org/10.1038/s41598-019-41897-5

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