Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice

Insertional mutagenesis is a powerful means of identifying cancer drivers in animal models. We used the Sleeping Beauty (SB) transposon/transposase system to identify activated oncogenes in hematologic cancers in wild-type mice and mice that express a stabilized cyclin E protein (termed cyclin ET74A...

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Detalles Bibliográficos
Autores principales: Loeb, Keith R., Hughes, Bridget T., Fissel, Brian M., Osteen, Nyka J., Knoblaugh, Sue E., Grim, Jonathan E., Drury, Luke J., Sarver, Aaron, Dupuy, Adam J., Clurman, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445099/
https://www.ncbi.nlm.nih.gov/pubmed/30940846
http://dx.doi.org/10.1038/s41598-019-41805-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445099/
https://www.ncbi.nlm.nih.gov/pubmed/30940846
http://dx.doi.org/10.1038/s41598-019-41805-x

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