Synthetic ligands for PreQ(1) riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

Riboswitches are naturally occurring RNA aptamers that regulate gene expression by binding to specific small molecules. Riboswitches control the expression of essential bacterial genes and are important models for RNA-small molecule recognition. Here, we report the discovery of a class of synthetic...

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Detalles Bibliográficos
Autores principales: Connelly, Colleen M., Numata, Tomoyuki, Boer, Robert E., Moon, Michelle H., Sinniah, Ranu S., Barchi, Joseph J., Ferré-D’Amaré, Adrian R., Schneekloth, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445138/
https://www.ncbi.nlm.nih.gov/pubmed/30940810
http://dx.doi.org/10.1038/s41467-019-09493-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445138/
https://www.ncbi.nlm.nih.gov/pubmed/30940810
http://dx.doi.org/10.1038/s41467-019-09493-3

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