Subnanomolar indazole-5-carboxamide inhibitors of monoamine oxidase B (MAO-B) continued: indications of iron binding, experimental evidence for optimised solubility and brain penetration

Pharmacological and physicochemical studies of N-unsubstituted indazole-5-carboxamides (subclass I) and their structurally optimised N1-methylated analogues (subclass II), initially developed as drug and radioligand candidates for the treatment and diagnosis of Parkinson’s disease (PD), are presente...

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Detalles Bibliográficos
Autores principales: Tzvetkov, Nikolay T., Antonov, Liudmil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445166/
https://www.ncbi.nlm.nih.gov/pubmed/28726524
http://dx.doi.org/10.1080/14756366.2017.1344980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445166/
https://www.ncbi.nlm.nih.gov/pubmed/28726524
http://dx.doi.org/10.1080/14756366.2017.1344980

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