Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

Novel series of bis- and tris-pyrrolo[1,2-a]quinoxaline derivatives 1 were synthesized and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biological results showed good antimalarial activity with IC(50) in the μM range. In attempting to inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Guillon, Jean, Cohen, Anita, Gueddouda, Nassima Meriem, Das, Rabindra Nath, Moreau, Stéphane, Ronga, Luisa, Savrimoutou, Solène, Basmaciyan, Louise, Monnier, Alix, Monget, Myriam, Rubio, Sandra, Garnerin, Timothée, Azas, Nadine, Mergny, Jean-Louis, Mullié, Catherine, Sonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445168/
https://www.ncbi.nlm.nih.gov/pubmed/28114821
http://dx.doi.org/10.1080/14756366.2016.1268608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445168/
https://www.ncbi.nlm.nih.gov/pubmed/28114821
http://dx.doi.org/10.1080/14756366.2016.1268608

Ejemplares similares