Cargando…

Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitors

Human S-adenosyl-homocysteine hydrolase (SAHH, E.C.3.3.1.1) has been considered to be an attractive target for the design of medicines to treat human disease, because of its important role in regulating biological methylation reactions to catalyse the reversible hydrolysis of S-adenosylhomocysteine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Weiwei, Li, Yanhua, Shan, Qiuli, Han, Tian, Li, Wencheng, He, Sheng, Zhu, Kongkai, Li, Yumei, Tan, Xiaojun, Gu, Jinsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445193/ https://www.ncbi.nlm.nih.gov/pubmed/28933241 http://dx.doi.org/10.1080/14756366.2017.1370584

Ejemplares similares

Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase
por: Kusakabe, Yoshio, et al.
Publicado: (2015)

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
por: Cao, Ji, et al.
Publicado: (2020)

S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system
por: Tehlivets, Oksana, et al.
Publicado: (2013)

S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic
por: Kailing, Lyn L., et al.
Publicado: (2018)

Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii
por: Manszewski, Tomasz, et al.
Publicado: (2017)

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
por: Greco, Carolina Magdalen, et al.
Publicado: (2020)

Evolutionary conservation and post-translational control of S-adenosyl-L-homocysteine hydrolase in land plants
por: Alegre, Sara, et al.
Publicado: (2020)

S-adenosyl-l-homocysteine Hydrolase: A Structural Perspective on the Enzyme with Two Rossmann-Fold Domains
por: Brzezinski, Krzysztof
Publicado: (2020)

S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase
por: Chen, Hui, et al.
Publicado: (2013)

S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum
por: Shi, Dongya, et al.
Publicado: (2021)

Allelic variation within the S-adenosyl-L-homocysteine hydrolase gene family is associated with wood properties in Chinese white poplar (Populus tomentosa)
por: Du, Qingzhang, et al.
Publicado: (2014)

Metal-cation regulation of enzyme dynamics is a key factor influencing the activity of S-adenosyl-l-homocysteine hydrolase from Pseudomonas aeruginosa
por: Czyrko, Justyna, et al.
Publicado: (2018)

S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
por: Ogawa, Takafumi, et al.
Publicado: (2022)

Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4(+) T-cell activation in a mouse heart transplantation model
por: Huang, Yajun, et al.
Publicado: (2020)

Homocysteine as a Risk Factor for Atherosclerosis: Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?
por: Tehlivets, Oksana
Publicado: (2011)

Selection of a Mimotope Peptide of S-adenosyl-l-homocysteine and Its Application in Immunoassays
por: Wu, Chun, et al.
Publicado: (2013)

Clinical value and expression of Homer 1, homocysteine, S-adenosyl-l-homocysteine, fibroblast growth factors 23 in coronary heart disease
por: Zhang, Zhixin, et al.
Publicado: (2022)

Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation
por: Tambunan, Usman Sumo Friend, et al.
Publicado: (2017)

S-Adenosyl homocysteine and DNA ends stimulate promiscuous nuclease activities in the Type III restriction endonuclease EcoPI
por: Peakman, Luke J., et al.
Publicado: (2009)

Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase
por: Singhal, Anshika, et al.
Publicado: (2013)

S-Adenosyl-S-carboxymethyl-l-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA
por: Byrne, Robert T., et al.
Publicado: (2013)

Human Valacyclovir Hydrolase/Biphenyl Hydrolase-Like Protein Is a Highly Efficient Homocysteine Thiolactonase
por: Marsillach, Judit, et al.
Publicado: (2014)

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
por: Li, Fei, et al.
Publicado: (2019)

Tyrosine, Cysteine, and S-Adenosyl Methionine Stimulate In Vitro [FeFe] Hydrogenase Activation
por: Kuchenreuther, Jon M., et al.
Publicado: (2009)

S-Adenosyl-l-Homocysteine Exhibits Potential Antiviral Activity Against Dengue Virus Serotype-3 (DENV-3) in Bangladesh: A Viroinformatics-Based Approach
por: Shill, Dipok Kumer, et al.
Publicado: (2023)

S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
por: Liu, Tsang-Pai, et al.
Publicado: (2015)

Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases
por: Rudenko, A. Yu., et al.
Publicado: (2022)

S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-Adenosyl-L-methionine’s chemistry, physiology and pharmacokinetics
por: Tsikas, Dimitrios, et al.
Publicado: (2017)

Structural insight into the recognition of S-adenosyl-L-homocysteine and sinefungin in SARS-CoV-2 Nsp16/Nsp10 RNA cap 2′-O-Methyltransferase
por: Mahalapbutr, Panupong, et al.
Publicado: (2020)

Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL
por: Ding, Wei, et al.
Publicado: (2016)

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
por: Noble, Christian G., et al.
Publicado: (2014)

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
por: Obata, Fumiaki, et al.
Publicado: (2015)

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila
por: Parkhitko, Andrey A., et al.
Publicado: (2016)

Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase
por: Tsao, Douglas, et al.
Publicado: (2011)

Automated One-pot Radiosynthesis of [(11)C]S-adenosyl Methionine
por: Zoppolo, Florencia, et al.
Publicado: (2017)

The Key Intermediate in Radical S-Adenosyl-methionine Catalysis: Caught in the Act
por: Rittle, Jonathan
Publicado: (2019)

A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis
por: Jin, Wen-Bing, et al.
Publicado: (2018)

Research Progress on N(6)-adenosylate Methylation RNA Modification in Heart Failure Remodeling
por: Yang, Yiqing, et al.
Publicado: (2023)

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites()
por: le Roux, Dina, et al.
Publicado: (2013)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
por: Steketee, Pieter C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_s4p5gmu5ml1dg9m27dd5a9d3cg