Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

A new series of quinazolinone compounds 16–34 incorporating isatin moieties was synthesized. The antitumor efficacy of the compounds against MDA-MB-231, a breast cancer cell line, and LOVO, a colon cancer cell line, was assessed. Compounds 20, 21, 22, 23, 25, 27, 28, 29, 30, 31, 32, 33, and 34 displ...

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Detalles Bibliográficos
Autores principales: El-Azab, Adel S., Al-Dhfyan, Abdullah, Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., Alkahtani, Hamad M., Al-Obaid, Abdulrahman M., Al-Gendy, Manal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445199/
https://www.ncbi.nlm.nih.gov/pubmed/28718672
http://dx.doi.org/10.1080/14756366.2017.1344981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445199/
https://www.ncbi.nlm.nih.gov/pubmed/28718672
http://dx.doi.org/10.1080/14756366.2017.1344981

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