3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led...

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Detalles Bibliográficos
Autores principales: Pustenko, Aleksandrs, Stepanovs, Dmitrijs, Žalubovskis, Raivis, Vullo, Daniela, Kazaks, Andris, Leitans, Janis, Tars, Kaspars, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445229/
https://www.ncbi.nlm.nih.gov/pubmed/28537099
http://dx.doi.org/10.1080/14756366.2017.1316720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445229/
https://www.ncbi.nlm.nih.gov/pubmed/28537099
http://dx.doi.org/10.1080/14756366.2017.1316720

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