Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

Nineteen new compounds containing tetrazole and/or cyanamide moiety have been designed and synthesised. Their structures were confirmed using spectroscopic methods and elemental analyses. Anti-inflammatory activity for all the synthesised compounds was evaluated in vivo. The most active compounds 4c...

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Detalles Bibliográficos
Autores principales: Lamie, Phoebe F., Philoppes, John N., Azouz, Amany A., Safwat, Nesreen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445242/
https://www.ncbi.nlm.nih.gov/pubmed/28587532
http://dx.doi.org/10.1080/14756366.2017.1326110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445242/
https://www.ncbi.nlm.nih.gov/pubmed/28587532
http://dx.doi.org/10.1080/14756366.2017.1326110

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