Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes

The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we investigated the function of BBK32 orthologues of the Lyme-associated Borrelia...

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Detalles Bibliográficos
Autores principales: Xie, Jialei, Zhi, Hui, Garrigues, Ryan J., Keightley, Andrew, Garcia, Brandon L., Skare, Jon T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445466/
https://www.ncbi.nlm.nih.gov/pubmed/30897158
http://dx.doi.org/10.1371/journal.ppat.1007659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445466/
https://www.ncbi.nlm.nih.gov/pubmed/30897158
http://dx.doi.org/10.1371/journal.ppat.1007659

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