Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models

AIMS/HYPOTHESIS: Bi-allelic loss-of-function mutations in the INSR gene (encoding the insulin receptor [INSR]) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have been shown to activate two mutant receptors, S323L and F382V. T...

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Detalles Bibliográficos
Autores principales: Brierley, Gemma V., Siddle, Kenneth, Semple, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445487/
https://www.ncbi.nlm.nih.gov/pubmed/29700562
http://dx.doi.org/10.1007/s00125-018-4606-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445487/
https://www.ncbi.nlm.nih.gov/pubmed/29700562
http://dx.doi.org/10.1007/s00125-018-4606-2

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