A single molecular distance predicts agonist binding energy in nicotinic receptors

Agonists turn on receptors because they bind more strongly to active (R*) versus resting (R) conformations of their target sites. Here, to explore how agonists activate neuromuscular acetylcholine receptors, we built homology models of R and R* neurotransmitter binding sites, docked ligands to those...

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Detalles Bibliográficos
Autores principales: Tripathy, Sushree, Zheng, Wenjun, Auerbach, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445573/
https://www.ncbi.nlm.nih.gov/pubmed/30635370
http://dx.doi.org/10.1085/jgp.201812212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445573/
https://www.ncbi.nlm.nih.gov/pubmed/30635370
http://dx.doi.org/10.1085/jgp.201812212

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