The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure

Human ether-à-go-go–related gene (hERG, KCNH2) voltage-activated potassium channels are critical for cardiac excitability. hERG channels have characteristic slow closing (deactivation), which is auto-regulated by a direct interaction between the N-terminal Per-Arnt-Sim (PAS) domain and the C-termina...

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Detalles Bibliográficos
Autores principales: Codding, Sara J., Trudeau, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445578/
https://www.ncbi.nlm.nih.gov/pubmed/30425124
http://dx.doi.org/10.1085/jgp.201812129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445578/
https://www.ncbi.nlm.nih.gov/pubmed/30425124
http://dx.doi.org/10.1085/jgp.201812129

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