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The hERG potassium channel intrinsic ligand regulates N- and C-terminal interactions and channel closure
Human ether-à-go-go–related gene (hERG, KCNH2) voltage-activated potassium channels are critical for cardiac excitability. hERG channels have characteristic slow closing (deactivation), which is auto-regulated by a direct interaction between the N-terminal Per-Arnt-Sim (PAS) domain and the C-termina...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445578/ https://www.ncbi.nlm.nih.gov/pubmed/30425124 http://dx.doi.org/10.1085/jgp.201812129 |