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Helix–strand interaction regulates stability and aggregation of the human mitochondrial membrane protein channel VDAC3
Voltage-dependent anion channels (VDACs) are β-sheet–rich transmembrane β-barrels that are vital for metabolite transport across the mitochondrial membrane. Under cellular stress, human VDACs hetero-oligomerize and coaggregate with proteins that can form amyloidogenic and neurodegenerative deposits,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445588/ https://www.ncbi.nlm.nih.gov/pubmed/30674561 http://dx.doi.org/10.1085/jgp.201812272 |