Sost Haploinsufficiency Provokes Peracute Lethal Cardiac Tamponade without Rescuing the Osteopenia in a Mouse Model of Excess Glucocorticoids

Glucocorticoid-induced secondary osteoporosis is the most predictable side effect of this anti-inflammatory. One of the main mechanisms by which glucocorticoids achieve such deleterious outcome in bone is by antagonizing Wnt/β-catenin signaling. Sclerostin, encoded by Sost gene, is the main negative...

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Detalles Bibliográficos
Autores principales: Javaheri, Behzad, Herbert, Eleanor, Hopkinson, Mark, Al-Jazzar, Ahmed, Pitsillides, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445804/
https://www.ncbi.nlm.nih.gov/pubmed/30664862
http://dx.doi.org/10.1016/j.ajpath.2018.12.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445804/
https://www.ncbi.nlm.nih.gov/pubmed/30664862
http://dx.doi.org/10.1016/j.ajpath.2018.12.007

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