Hypomethylation at non-CpG/CpG sites in the promoter of HIF-1α gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1α expression in breast cancer

HIF-1α has a broad impact on tumors, including enhanced utilization of glucose, tumor cell stemness, migration, metastasis and so on. In pilot study, we found that the expression of HIF-1α significantly increased in breast cancer cell lines and tissue samples with higher malignant behaviors and decr...

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Detalles Bibliográficos
Autores principales: Li, Chun, Xiong, Wei, Liu, Xiong, Xiao, Wenjun, Guo, Yuxian, Tan, Junyu, Li, Yaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445832/
https://www.ncbi.nlm.nih.gov/pubmed/30940798
http://dx.doi.org/10.1038/s41389-019-0135-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445832/
https://www.ncbi.nlm.nih.gov/pubmed/30940798
http://dx.doi.org/10.1038/s41389-019-0135-1

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