t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

Introduction: Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS, plasmin, the effector protease, has been reported t...

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Detalles Bibliográficos
Autores principales: Draxler, Dominik F., Lee, Felix, Ho, Heidi, Keragala, Charithani B., Medcalf, Robert L., Niego, Be'eri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445967/
https://www.ncbi.nlm.nih.gov/pubmed/30972077
http://dx.doi.org/10.3389/fimmu.2019.00591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445967/
https://www.ncbi.nlm.nih.gov/pubmed/30972077
http://dx.doi.org/10.3389/fimmu.2019.00591

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