Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication

BACKGROUND: HIV integrase (IN) and its cellular cofactors, including lens-epithelium-derived growth factor (LEDGF/p75), Ku70, p300, and Rad52, are subject to small ubiquitin-like modifier (SUMO) modification. In addition to covalent SUMOylation, SUMO paralogs can also noncovalently bind proteins thr...

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Detalles Bibliográficos
Autores principales: Zheng, Yingfeng, Jayappa, Kallesh Danappa, Ao, Zhujun, Qiu, Xiangguo, Su, Ruey-Chyi, Yao, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446281/
https://www.ncbi.nlm.nih.gov/pubmed/30940169
http://dx.doi.org/10.1186/s12985-019-1134-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446281/
https://www.ncbi.nlm.nih.gov/pubmed/30940169
http://dx.doi.org/10.1186/s12985-019-1134-8

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