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An average-case sublinear forward algorithm for the haploid Li and Stephens model

BACKGROUND: Hidden Markov models of haplotype inheritance such as the Li and Stephens model allow for computationally tractable probability calculations using the forward algorithm as long as the representative reference panel used in the model is sufficiently small. Specifically, the monoploid Li a...

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Detalles Bibliográficos
Autores principales: Rosen, Yohei M., Paten, Benedict J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446408/
https://www.ncbi.nlm.nih.gov/pubmed/30988694
http://dx.doi.org/10.1186/s13015-019-0144-9