MAP7 family proteins regulate kinesin-1 recruitment and activation

Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes. Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four mammalian MAP7 family members bind to kinesin-1. In HeLa cells, MAP7, MAP7D1, and MAP7D3 act redundantly to enable kinesin-1–d...

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Detalles Bibliográficos
Autores principales: Hooikaas, Peter Jan, Martin, Maud, Mühlethaler, Tobias, Kuijntjes, Gert-Jan, Peeters, Cathelijn A.E., Katrukha, Eugene A., Ferrari, Luca, Stucchi, Riccardo, Verhagen, Daan G.F., van Riel, Wilhelmina E., Grigoriev, Ilya, Altelaar, A.F. Maarten, Hoogenraad, Casper C., Rüdiger, Stefan G.D., Steinmetz, Michel O., Kapitein, Lukas C., Akhmanova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446838/
https://www.ncbi.nlm.nih.gov/pubmed/30770434
http://dx.doi.org/10.1083/jcb.201808065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446838/
https://www.ncbi.nlm.nih.gov/pubmed/30770434
http://dx.doi.org/10.1083/jcb.201808065

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