Cargando…
MAP7 family proteins regulate kinesin-1 recruitment and activation
Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes. Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four mammalian MAP7 family members bind to kinesin-1. In HeLa cells, MAP7, MAP7D1, and MAP7D3 act redundantly to enable kinesin-1–d...
Autores principales: | Hooikaas, Peter Jan, Martin, Maud, Mühlethaler, Tobias, Kuijntjes, Gert-Jan, Peeters, Cathelijn A.E., Katrukha, Eugene A., Ferrari, Luca, Stucchi, Riccardo, Verhagen, Daan G.F., van Riel, Wilhelmina E., Grigoriev, Ilya, Altelaar, A.F. Maarten, Hoogenraad, Casper C., Rüdiger, Stefan G.D., Steinmetz, Michel O., Kapitein, Lukas C., Akhmanova, Anna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446838/ https://www.ncbi.nlm.nih.gov/pubmed/30770434 http://dx.doi.org/10.1083/jcb.201808065 |
Ejemplares similares
-
Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends
por: Serra-Marques, Andrea, et al.
Publicado: (2020) -
Kinesin-4 KIF21B is a potent microtubule pausing factor
por: van Riel, Wilhelmina E, et al.
Publicado: (2017) -
Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells
por: Hooikaas, Peter Jan, et al.
Publicado: (2020) -
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon
por: Pan, Xingxiu, et al.
Publicado: (2019) -
Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations
por: Bianchi, Sarah, et al.
Publicado: (2016)