Kinesin-binding protein ensures accurate chromosome segregation by buffering KIF18A and KIF15

Mitotic kinesins must be regulated to ensure a precise balance of spindle forces and accurate segregation of chromosomes into daughter cells. Here, we demonstrate that kinesin-binding protein (KBP) reduces the activity of KIF18A and KIF15 during metaphase. Overexpression of KBP disrupts the movement...

Descripción completa

Detalles Bibliográficos
Autores principales: Malaby, Heidi L.H., Dumas, Megan E., Ohi, Ryoma, Stumpff, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446846/
https://www.ncbi.nlm.nih.gov/pubmed/30709852
http://dx.doi.org/10.1083/jcb.201806195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446846/
https://www.ncbi.nlm.nih.gov/pubmed/30709852
http://dx.doi.org/10.1083/jcb.201806195

Ejemplares similares