MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

Cyclin B–dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter role is mediated through phosphorylation of the checkpoint kinase MPS1 and other spindle checkpoint proteins. We find that CDK1-CCNB1 localizes...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfonso-Pérez, Tatiana, Hayward, Daniel, Holder, James, Gruneberg, Ulrike, Barr, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446853/
https://www.ncbi.nlm.nih.gov/pubmed/30674583
http://dx.doi.org/10.1083/jcb.201808015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446853/
https://www.ncbi.nlm.nih.gov/pubmed/30674583
http://dx.doi.org/10.1083/jcb.201808015

Ejemplares similares