Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing

In response to DNA damage, the transcription factor p53 accumulates in a series of pulses. While p53 dynamics play a critical role in regulating stress responses, how p53 pulsing affects target protein expression is not well understood. Recently, we showed that p53 pulses generate diversity in targe...

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Detalles Bibliográficos
Autores principales: Hanson, Ryan L., Porter, Joshua R., Batchelor, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446860/
https://www.ncbi.nlm.nih.gov/pubmed/30745421
http://dx.doi.org/10.1083/jcb.201803063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446860/
https://www.ncbi.nlm.nih.gov/pubmed/30745421
http://dx.doi.org/10.1083/jcb.201803063

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